Images displayed in the coronal orientation from MRI and DTI studies of a 61-year-old healthy man (upper images) and a 60-year-old alcoholic man (lower images). The high-resolution MRI slices are at the same locations as the fractional anisotropy images of the DTI panels. Note on the MRI the thinner corpus callosum displaced upward by enlarged ventricles and, on the DTI, less well delineated white matter tracts in the alcoholic man compared with the healthy man.

Source: Rosenbloom, M., Sullivan, E.V., and Pfefferbaum, A. Using magnetic resonance imaging and diffusion tensor imaging to assess brain damage in alcoholics. Alcohol Research & Health 27(2):146–152, 2003.